Oxford scientist behind Covid vaccine hopes approval 'isn't far off'

Oxford scientist behind Covid vaccine hopes approval 'isn't far off'

Oxford University scientist behind Covid vaccine hopes UK approval ‘isn’t too far off’ amid hopes it will be rolled out before Christmas

  • Sarah Gilbert, from Oxford University, said she hoped approval wasn’t far off
  • She added that she endured sleepless nights during the jabs development
  • If approved, it will add 100million doses to the UK’s arsenal against Covid-19 

The lead researcher behind the Oxford University coronavirus vaccine said she hopes the moment the jab is approved and rolled out ‘isn’t too far off’ as she spoke about the sleepless nights she endured during its development.

Sarah Gilbert, professor of vaccinology at the university, said she never doubted what she and her team of researchers were doing, but at times had worried about things they might have missed along the way.

She compared her work to running a small business, giving an insight into how the scientists pulled off the huge task.

She told BBC Radio 4’s Today programme: ‘Running a research group is a bit like running a small business. I have to think about where the money’s going to come from, what staff I’ve got, how long their contracts are. Because they’re only funded for the contracts that I have funding to pay them for.

‘So it is like running a business and I unfortunately don’t spend as much of my time working on the science as I would like to but it’s necessary to keep all the other things going in order to be able to do science that really has impact.’

The Oxford Covid-19 jab (pictured) could be approved by regulators very soon, its developer Professor Sarah Gilbert said today

Professor Gilbert, pictured, also said she suffered sleepless nights during its development

GPs told to use extra dose of Pfizer’s Covid vaccine as NHS updates advice 

GPs have been told to use a sixth dose of Pfizer’s Covid-19 vaccine by the NHS, after it emerged yesterday that its vials contain an extra shot of the jab.

Britain’s medical regulator says every vial – the small glass container which holds the liquid vaccine – holds five doses, administered in 0.3ml shots. But it admitted that once the vaccine is diluted before being given out, a vial holds as much as 2.25ml – enough for seven and a half doses.

Doctors and nurses administering the vaccine have now been told to use one of the extra doses ‘at their discretion’, in a weekly webinar with NHS England. 

The sixth dose will boost the amount of vaccine available in the UK by 20 per cent, allowing an extra 160,000 people to get the shot with the 800,000 delivered this month alone. It could also mean up to 8million more people could be vaccinated using the Pfizer jab once the UK receives its total order of 40million doses. 

The UK Medicines and Healthcare products Regulatory Agency (MHRA) confirmed to MailOnline yesterday that ‘small’ amounts of the jab are going unused, and that the vials contain extra in case of spills and because some gets stuck in the syringe.

It insisted, however, that ‘additional product is not being wasted’ because the extra liquid was never intended to be used and is only there as a backup.

The mother of grown-up triplets said she knew she could work on little sleep and had endured some sleepless nights along the way this year.

She said: ‘At the start of the year I did have sleepless nights, wondering what it was that we haven’t thought about – what problem was going to trip us up, because nobody had realised that we needed to do it, but, actually, that never happened. Somebody had always thought of everything.’

Acknowledging that she was known to email at 4am, she said this year she would ‘wake up in the early hours of the morning and think about something that I really needed to do and then I think of a second thing and then a third thing and then I just had to go and deal with it before I forgot all the details that have suddenly become clear to me’.

She recalled first reading about the new virus emerging in China on New Year’s Day as she looked at a website which reports on disease outbreaks.

Describing the team’s work on creating a vaccine, she said the final parts of the jab were designed in a weekend.

She said: ‘We’d already made a lot of decisions about how we were going to design the vaccine but it was just the parts that we had to wait for the actual sequence to get, and then that was put together.

‘But a lot of it is using methods we’d used previously – there’s only small parts of it that are unique to this vaccine.’

She said the biggest challenge had been the time between moving from manufacturing on a small scale to a much larger scale which is where pharmaceutical giant AstraZeneca came in.

She said: ‘There was that point in between going from our very small scale manufacturing to AstraZeneca’s very large scale manufacturing, that we had to bridge the gap and keep the clinical trials going as quickly as we possibly could and we needed vaccine supply to do that and that was a difficult time.’

Oxford data indicates the vaccine, which is currently being considered by the Medicines and Healthcare products Regulatory Agency for approval, has 62 per cent efficacy when one full dose is given followed by another full dose, but when people were given a half dose followed by a full dose at least a month later, its efficacy rose to 90 per cent.

The combined analysis from both dosing regimes resulted in an average efficacy of 70.4 per cent.

Prof Gilbert said the results had pleased but also ‘intrigued’ researchers and ‘immediately led to thoughts of wanting to do more work’.

She said: ‘So it wasn’t quite the climax that it might have been.

‘But we’re we’re very happy with with the way the vaccine is performing, really looking forward to the point where people can start to be vaccinated outside of clinical trials.

‘Obviously I can’t prejudge that moment, the regulator’s have to be given their time to make their decisions but I really hope that that moment isn’t too far off.’

Source: Read Full Article