Manchester United, Liverpool, Tottenham and Manchester City all safely negotiated their groups to ensure a place in Monday's draw for the last-16.
But only City topped their group, which means the other three sides face the real prospect of being paired with one of the giants of European football.
And with teams from the same country not able to face each other, it means some clubs are more likely be drawn against one team than others.
Add into the mix that no teams who appeared in the same group can be drawn against each other, and the outcome is becoming more predictable.
SunSport takes a look at the possible outcomes from the round of 16 draw.
It is only possible for Pep Guardiola's side to be drawn against four teams in the last-16 – Atletico Madrid, Roma, Schalke or Ajax.
And given there are two Spanish teams who also topped their groups, it slightly increases the prospect of Atletico being drawn to face City.
Statistician Mister Chip crunched the numbers and there is a 28.912 per cent chance Guardiola will have to face Diego Simeone's tough side in the round of 16.
A trip to Amsterdam is least likely, with a reduced 19.978 per cent chance of Ajax being drawn out of the pot.
Jose Mourinho knows he can face Porto in the knockout stages, the club he led to his first Champions League trophy.
But that is least likely of the six outcomes United can get in the draw at 14.672 per cent.
Instead they have the most chance of getting Borussia Dortmund in the next round – although ironically they are also the team both Tottenham and Liverpool statistically are most likely to face as well.
Yet a meeting with defending champions Real Madrid, another former Mourinho team, is another of their most likely draws.
Spurs climbed a mountain to secure safe passage through the group having taken just one point from their opening three matches – so they will fancy their chances of progressing no matter who they get.
Like United, Dortmund are just about the most likely – but you could forgive them for wanting the least likely option in the 14.781 per cent chance, Porto.
Lying in wait, though, could well be two teams they face in the competition last season – Real Madrid, who they beat in the group, and their quarter-final conquerers Juventus.
No-one will hold an fears for Jurgen Klopp's side after their scintillating march to the final last year – and their is a 17.190 per cent chance they will be drawn to face Real again.
Barcelona are almost as likely to be paired with them in a match that would be a real test of the new-look Reds defence.
But a Klopp reunion with Dortmund is the most likely, although whether the Anfield boss would like that is open to question.
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