The Premier League champions are priced at 200/1 to win by the same scoreline at the Pirelli Stadium.
Pep Guardiola's men are priced at 1/7 to win the game, leaving Burton as the huge underdogs at 16/1 to cause an upset.
The bookies believe it is more likely City will win by five or more goals at 7/1 than Burton winning the fixture.
Alex Apati of Ladbrokes said: "All the signs point towards another routine win for Pep's men, while 9-0 would by far be the most costly scoreline in the book."
Gabriel Jesus scored four, with Kevin de Bruyne, Oleksandr Zinchenko, Phil Foden, Kyle Walker and Riyad Mahrez also netting in the first leg of the semi final against the League One outfit.
Elsewhere in the competition Tottenham travel to Chelsea for a place in the Carabao Cup final.
Spurs boast a slender 1-0 lead after Harry Kane penalty, which was awarded following a controversial VAR decision.
See SunSport's top tips ahead of the game for our betting guide for the clash at Stamford Bridge.
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