The BBC will screen the fourth round showdown but the timing is sure to annoy supporters aiming to travel to the January 25 kick-off.
Late-night games are inconvenient for punters, especially those coming down from Manchester or further afield.
The Football Supporters' Federation branded the plans a "faff" soon after the TV fixtures were announced.
Red Devils fans travelling via rail will likely only be able to catch the last train at 11pm, which arrives at Piccadilly at almost 2am.
And they have voiced their displeasure at the decision on Twitter – accusing The FA of not caring about people who attend games.
Even the Gooners faithful have slammed the call, with blogger Dan Critchlow expressing his sympathy for rival fans.
United beat Reading, while the Gunners toppled Blackpool to reach this stage.
And both with be mindful of the other as both clubs boast incredible records against each other.
United have eliminated Arsenal from the FA Cup on seven occasions – more than any other side.
However, Arsenal have knocked their rivals out of the same tournament more than any other team in the competition (also seven).
Better yet, Arsenal and United lead the way in total FA Cup wins – with 13 and 12 trophies apiece respectively.
But this year, only one can progress, with the Gunners winning the trophy in three of the last last five seasons.
Most recently, Arsenal won the crown in the 2016-17, 2014-15 and 2013-14 seasons, while Man United last triumphed in 206.
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