Unai Emery has admitted the League One side are not in the "best moment" and vowed to show them respect at Bloomfield Road.
The Seasiders have averaged a capacity of just 4,000 this season following continuous protests against the club's owner.
And it was reported before the third round FA Cup clash that just 2977 home seats had been filled.
Around 5,200 Arsenal fans are expected to travel to Bloomfield Road – which has a total capacity of 14,413.
Blackpool Fans have decided to boycott the club as part of their "Not a penny more" campaign.
Lancashire police will be out in force on Saturday, with between 20-30 officers expected to be inside the ground.
The police have warned: "Anybody entering the field of play without permission will be committing criminal offences and will be dealt with appropriately."
Before the 1-0 defeat to Sunderland, protest pamphlets were being distributed and Oyston Out scarves were on sale.
Emery has insisted that the Gunners will show respect to their opponents during his first FA Cup encounter.
He said: "When we played here against them in the Carabao Cup, we knew this history of this club.
"They aren't in the best moment for that. But here against us at the Emirates they played very competitively and gave us a lot of difficult moments.
"I have a big respect for each team and I know they are one team now not in the best moment, but the respect is there.
"It's a very big opportunity for them to play against us with their supporters and live this important moment, finding the chances against us."
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